Andy Murray. World number 14 Berrettini came through 6-4, 6-4, 6-7 (1/7), 6-3, crunching 18 aces and 55 winners in total on Arthur Ashe Court.
A semi-finalist in 2019 and quarter-finalist last year, the 26-year-old goes on to face Spain's Alejandro Davidovich Fokina for a last-eight spot. "I wasn't aggressive enough in the third set but I was feeling better in the fourth.
I had my chances and took them, finally," said the Italian. Berrettini had defeated Murray in the Stuttgart final in June and was in control from the start on Friday.
Murray double-faulted to hand the Italian the only break of the opening set in the seventh game and was a break to the good in the first game of the second set.
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