Sbu Nkosi and Marcon van Staden will not be joining the Springboks on their end-of-year tour because of injuries picked up on United Rugby Championship duty for the Bulls.
SA Rugby confirmed the news on Tuesday after coach Jacques Nienaber named his side for this weekend's clash against Ireland in Dublin.
Both players suffered rib injuries in the Bulls' victory over the Sharks on Sunday, and it was further confirmed that they would not be joining up with the national squad.
No replacements will be called up. 15 Cheslin Kolbe, 14 Kurt-Lee Arendse, 13 Jesse Kriel, 12 Damian de Allende, 11 Makazole Mapimpi, 10 Damian Willemse, 9 Jaden Hendrikse, 8 Jasper Wiese, 7 Pieter-Steph du Toit, 6 Siya Kolisi (captain), 5 Lood de Jager, 4 Eben Etzebeth, 3 Frans Malherbe, 2 Malcolm Marx, 1 Steven KitshoffSubstitutes: 16 Bongi Mbonambi, 17 Ox Nche, 18 Vincent Koch, 19 Franco Mostert, 20 Deon Fourie, 21 Kwagga Smith, 22 Faf de Klerk, 23 Willie le RouxKick-off on Saturday night is at 19:30.