Manager Erik ten Hag could be without up to six players for Manchester United's trip to St Mary's to face Southampton on Saturday lunchtime.
United will resume their campaign with the ambition of getting back to winning ways after suffering successive defeats prior to the international break.
After losing 2-1 to Brighton & Hove Albion in their first away game of the season, the Reds were beaten 3-0 by Liverpool at Old Trafford last time out.
It means Ten Hag and his players are already under a huge degree of pressure to get back on track this weekend. On paper, it strikes as being a golden opportunity to get three points on the board, with Southampton having lost each of their first three league games. READ MORE: United managers have got it right and wrong with trophy talk READ MORE: Erik ten Hag has been left with no choice but to give United's fans what they want Ahead of the long trip south, United will be hoping to get at least two significant boosts on the injury front.