Alejandro Garnacho and Fred struck late as Manchester United came from behind to beat West Ham 3-1 and reach the FA Cup quarter-finals on Wednesday but Tottenham were stunned by Championship side Sheffield United.
In the evening's other fifth-round ties, fourth-tier Grimsby embarrassed Premier League strugglers Southampton 2-1 and Burnley beat 10-man Fleetwood 1-0.
Manchester United, who made six changes to the team that started Sunday's League Cup final win against Newcastle, lacked fluency in front of an expectant Old Trafford crowd.
United goalkeeper David de Gea thwarted Michail Antonio when the West Ham forward bore down on goal midway through the opening period and Emerson Palmieri flashed an inviting ball across the box.
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