Wales No. 8 Taulupe Faletau returns from injury just days ahead of Steve Tandy's autumn squad announcement as he takes on former club Dragons at Rodney Parade on Friday night.
The 34-year-old will play his first game of the season for Cardiff after recovering from a calf injury, facing Wales rival Aaron Wainwright.
Dragons head coach Filo Tiatia has made 10 changes from the side that lost 49-0 to Glasgow, with the Men of Gwent looking to end a decade of Cardiff dominance in this fixture.
The Dragons have lost 19 matches in all competitions against Cardiff and the past 20 league matches between the two sides. The last league win over Cardiff came in December 2014, although they did beat them in the Challenge Cup quarter-final in April 2015.
As for Cardiff, they welcome back five Wales internationals - with Josh Adams, Ben Thomas, Corey Domachowski and Alex Mann back alongside Faletau.
Jacob Beetham switches to outside centre for his fourth different position in as many games, while injured lock Teddy Williams is replaced by former Dragons second-row George Nott.
Kick-off is at 7.45pm, with the match being broadcast on Premier Sports and S4C. You can also follow the action in our live blog below.
Dragons RFC: Angus O’Brien (C), Rio Dyer, Aneurin Owen, Harri Ackerman, Fine Inisi, Tinus de Beer, Rhodri Williams; Wyn Jones, Brodie Coghlan, Robert Hunt, Seb Davies, Ben Carter (C), Shane Lewis-Hughes, Harry Beddall, Aaron Wainwright
Replacements: Oli Burrows, Rodrigo Martinez, Dillon Lewis, Matthew Screech, Ryan Woodman, Niall Armstrong, Cai Evans, Huw Anderson.
Cardiff Rugby: Cam Winnett; Josh Adams, Jacob Beetham, Ben Thomas, Tom Bowen; Callum Sheedy, Aled Davies; Corey Domachowski, Liam Belcher (C), Keiron Assiratti, Josh McNally,
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