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In his pre-Tottenham press conference, Erik ten Hag noted how the packed schedule ahead of the World Cup break is increasing the frequency of injuries for all clubs this season.
Anhony Martial will not be available for Manchester United against Tottenham but Christian Eriksen could return against his former club.
Cristiano Ronaldo seems to have received a new lease of life at Manchester United. The Portuguese star scored the 700th club goal of his career to earn United a 2-1 victory at Everton, raising hopes of a return to form.
Victor Lindelof is the fourth-choice centre-back at Manchester United and he showed why in his only start of the season so far.
Manchester United's recent history with loanees has not been great. Last season for every James Garner success story at Nottingham Forest fans saw the likes of Axel Tuanzebe play 110 minutes in six months for Napoli and Amad failing to become a starter at Rangers.
Raphael Varane's ankle injury is not expected to keep the Manchester United defender sidelined for a long-term period.
Marcus Rashford and Anthony Martial have returned to training ahead of the Manchester derby but under-fire Harry Maguire will be absent – a player United boss Erik ten Hag is convinced will turn things around.