Manchester City will have fond memories of taking on RB Leipzig from last season's Champions League title run. After a tight 1-1 draw in Germany, Erling Haaland became the third player to hit five goals in a single match in the 7-0 thrashing in the last-16 second leg at the Etihad.
Since then, Pep Guardiola has nabbed one of the Bundesliga club's stars in Josko Gvardiol. Gvardiol will be lining up alongside Haaland this time after a torrid night against the Norwegian in March.
His former side are on a roll coming into this one, though, having held Bayern Munich to a 2-2 draw on Saturday to stretch their unbeaten run to serve.
In fact, they have lost just once in nine games this term. Meanwhile, City are expected to pay tribute to Francis Lee as they take to the field for the first time since the club legend's passing on Monday aged 79.