"After two seasons in the capital, Leo Messi's adventure with Paris Saint-Germain will come to a conclusion at the end of the 2022-23 season," the club said in a widely expected announcement.
The club said the 35-year-old would play some role in the Ligue 1 match against Clermont at the Parc des Princes on Saturday.
The Argentinian was signed two seasons ago from Barcelona to help PSG win an elusive Champions League, but he failed in that aim.
The French club were beaten in the Champions League last 16 by Real Madrid last season and suffered the same fate this year at Bayern Munich's hands.
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