Manchester United are not the only Premier League side hampered by high-profile injuries right now. During their 1-0 win against Wolves at Old Trafford on Monday night, United were dealt a fitness blow when Lisandro Martinez had to be withdrawn at half-time with an ankle problem.
He joins Amad Diallo, Tyrell Malacia and Rasmus Hojlund - among others - on the treatment table at Carrington. As for treble-winning neighbours Manchester City, they have been rocked by the news that Belgium captain Kevin De Bruyne will be on the side-lines for four months.
De Bruyne was forced off just 22 minutes into their 3-0 win over Burnley on Friday night and is set to undergo surgery to correct the issue.
Fellow top-four contenders Arsenal, Chelsea, Liverpool, Newcastle United and Tottenham Hotspur are not without their own selection concerns, either, with Jurrien Timber (Arsenal) and Christopher Nkunku (Chelsea) nursing injuries.