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College football Week 4 - Alabama issues, Colorado-Oregon expectations, picks, more - ESPN

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For Week 4 of the season, find a seat on the couch and stay there. From Florida State-Clemson to start the day to an afternoon block that features Colorado-Oregon, UCLA-Utah and Ole Miss-Alabama to prime-time showdowns with Ohio State-Notre Dame and Iowa-Penn State, the week is absolutely loaded with huge games with potentially huge College Football Playoff stakes.

After a dramatic few weeks, Colorado goes up against an Oregon offense that's averaging 58 points per game. The Buffaloes are a 20.5-point underdog against Oregon, per Caesars Sportsbook.

Earlier this season, the Buffaloes defeated TCU despite being 21-point underdogs. Since the FBS/FCS split in 1978, according to ESPN Stats & Information, only three teams have won multiple games as an underdog of 20-plus points in a season.

In South Bend, Indiana, the Irish and Buckeyes are meeting for just the eighth time in their history. Ohio State is 5-2 in the series and won last season's Week 1 meeting.

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