Borussia Dortmund captain Marco Reus bas been omitted by head coach Hansi Flick from Germany's squad for the World Cup, while 2014 World Cup hero Mario Goetze makes a shock return after a five-year absence.
Flick also selected uncapped duo, Werder Bremen striker Niklas Fuellkrug and 17-year-old Dortmund forward Youssouffa Moukoko.
Alongside Reus, there were several high-profile absences in the squad, including Reus' Dortmund teammate Mats Hummels and Inter Milan wing-back Robin Gosens.
Former Chelsea striker Timo Werner was ruled out in early November due to a leg injury.
Goalkeeper Manuel Neuer has overcome recent shoulder issues to be named as captain, while his veteran Bayern Munich teammate Thomas Mueller has been included despite a back issue which has restricted his appearances since late September.
Flick confirmed Reus would miss the tournament due to an ankle problem he suffered in September.
Reus, 33, missed the 2014 World Cup due to a foot injury picked up in the last friendly before leaving for South America, while he was also cut for the 2016 Euros due to fitness issues.
Reus played his only World Cup in Russia in 2018, scoring one of Germany's two goals in the tournament as they were eliminated in the group stage.
Squad
Goalkeepers: Manuel Neuer (captain) (Bayern Munich), Marc-Andre ter Stegen (Barcelona/ESP), Kevin Trapp (Eintracht Frankfurt)
Defence: Armel Bella Kotchap (Southampton/ENG), Matthias Ginter (Freiburg), Christian Guenter (Freiburg), Thilo Kehrer (West Ham United/ENG), Lukas Klostermann (RB Leipzig), David Raum (RB Leipzig/), Antonio Ruediger (Real Madrid/ESP), Nico Schlotterbeck (Borussia Dortmund), Niklas Süle (Borussia Dortmund)
Midfield and forwards: Karim Adeyemi (Borussia Dortmund), Julian Brandt
FIFA World Cup Qatar 2022™
Chelsea
Bayern Munich
Niklas Süle
Borussia Dortmund
Timo Werner
Robin Gosens
Antonio Ruediger
Matthias Ginter
Manuel Neuer
Nico Schlotterbeck
David Raum
Marco Reus
Thomas Mueller
Kevin Trapp
Mats Hummels
Julian Brandt
Hansi Flick