Wimbledon 2022: Andy Murray loses to John Isner in the second round

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The recurring cries of "Come on, Andy!" at Centre Court meandered somewhere along the continuum from pushing to pleading as two-time champion Andy Murray’s shortest stay at Wimbledon came to a close.

Unable to overcome big John Isner’s big serves, the way he always has in the past, the revered Murray lost in the second round to the 20th-seeded American 6-4, 7-6 (4), 6-7 (3), 6-4 on Wednesday night at the All England Club, capping a disappointing afternoon and evening in the grass-court Grand Slam tournament’s main stadium for the locals.

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Britain's Andy Murray waves after losing the singles tennis match against John Isner of the US on day three of the Wimbledon tennis championships in London, Wednesday, June 29, 2022.  (AP Photo/Alastair Grant)

Prior to Murray vs. Isner, the host country’s other leading player, reigning U.S. Open champion Emma Raducanu, was eliminated by Caroline Garcia of France 6-3, 6-3.

Asked whether he plans to be back a year from now, the 35-year-old Murray replied: "It depends on how I am physically. If physically I feel good, we’ll try to keep playing. But it’s extremely difficult, with the problems I’ve had with my body the last few years, to make predictions."

Murray needed multiple operations on his hip and now has an artificial joint. He also recently dealt with an abdominal issue that hampered his preparations last week.

In addition to becoming Britain’s first men’s singles title winner in 77 years at Wimbledon when he claimed the trophy in 2013 — and adding another in 2016 — Murray always had managed to make it to at least the third round in his 13 prior