Premier League high-flyers Newcastle suffered a shock FA Cup exit against third tier Sheffield Wednesday, while top-flight strugglers Nottingham Forest and Bournemouth were also dumped out by lower-league opposition on Saturday.
Elsewhere on a hectic day of third round action, Harry Kane moved closer to becoming Tottenham's all-time record goalscorer as he netted in the 1-0 win against Portsmouth.
Ryan Reynolds and Rob McElhenney, the Hollywood actors who co-own Wrexham, led the celebrations on social media after their non-league side's surprise 4-3 victory at second tier Coventry.
But it was Wednesday who stole the show with their impressive 2-1 victory at Hillsborough against a Newcastle team sitting in third place in the Premier League.
Eddie Howe's side were unbeaten in their previous 15 games in all competitions, but Wednesday, currently second in League One, have now gone undefeated in 10 successive matches after Josh Windass's double stunned the Magpies.
Wednesday went ahead in the 52nd minute when Windass, who looked in an offside position, diverted Dennis Adeniran's ball across from close-range.
Windass scored his second 13 minutes later, coolly converting after being put through by Michael Smith.
Newcastle reduced the deficit in the 68th minute when Bruno Guimaraes poked home from close-range, but Chris Wood squandered a golden opportunity to equalise as he fired over from 10 yards.
On a day of shocks that showed the FA Cup can still thrill despite its diminished status, National League Wrexham enjoyed one of the more memorable results in the competition's recent history.
Sam Dalby and Elliot Lee scored to give Wrexham a dream start before Ben Sheaf got one back for Coventry.
Thomas O'Connor grabbed Wrexham's third
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