NFL Week 15 picks, predictions, schedule, odds, fantasy tips - ESPN

The Week 15 NFL schedule for the 2025 season brings some exciting matchups.

The Chargers seek their first sweep over the Chiefs since 2013, the Patriots can clinch the AFC East title with a win Sunday, and two of the best defenses in the league — Green Bay and Denver — will battle it out. We could also see 44-year-old Philip Rivers make his Colts debut, as well as rookie QB Brady Cook's first start for the Jets.

We have you covered with everything you need to know. Our NFL Nation reporters take you inside the locker room with the best thing they heard this week, and ESPN Research provides a key stat to know and a betting nugget for each contest. Plus, analytics writer Seth Walder makes a bold prediction for each matchup, and fantasy analyst Eric Moody shares fantasy football intel. We also have Football Power Index (FPI) game projections, and three analysts — Pamela Maldonado, Moody and Walder — give us final score picks for every game. To top it off, we've included ramifications for each game — from playoff berths to positioning in the 2026 NFL draft.

Let's get into the full Week 15 slate, which culminates with the «Monday Night Football» matchup between the Dolphins and Steelers on ESPN. (Game times are Sunday unless otherwise noted.)

Jump to a matchup:
LAC-KC | BUF-NE | BAL-CIN
ARI-HOU | LV-PHI | WSH-NYG
CLE-CHI | NYJ-JAX | DET-LAR
IND-SEA | GB-DEN | TEN-SF
CAR-NO | MIN-DAL | MIA-PIT

Thursday: ATL-TB

1 p.m. ET | CBS | KC -5.5 (41.5 O/U)

What we're hearing on the Chargers: Los Angeles is looking to sweep the Chiefs for the first time since the 2013 season. A win would move the Chargers to double-digit victories for the second straight season under coach Jim Harbaugh and closer to catching the Broncos, who have a