A repeat of last year's quarter-final, which could lead to a repeat of last year's semi.
The last Irish team standing will look to go one step closer to a home final, with Leinster hosting the two-time champions Leicester Tigers at the Aviva Stadium.
Last May, the Tigers were easily disposed of by Leo Cullen's side in the last eight, first-quarter tries from Josh van der Flier and Robbie Henshaw putting them on their way, and while the English side did rally in the second half, they never looked like mounting a real comeback.
With home advantage, Leinster are big favourites to do similar to the Premiership champions, and set up a potential semi-final repeat against Toulouse, who are expected to do the business at home to the Cell C Sharks.
With capacity of the Aviva Stadium reduced to 27,000 because of the short turnaround between games, Lansdowne Road won't be hopping to the same degree as last week's sold-out ground, but the Good Friday crowd should provide more than enough atmosphere to give the home side an advantage.
Saturday's 30-15 win against Ulster was a 20th victory of the season in just 21 games for Leinster, the only blemish being the 22-22 draw with the Stormers a couple of weeks back.
And with most of this week's line-up set to remain in Dublin for the next couple of weeks, while a mix of wider squad players and academy prospects travel to South Africa for the two remaining URC games, Leo Cullen will send out a fully loaded team.
Leicester, meanwhile, will have one eye on their Premiership meeting with Exeter next week, as they look to secure their spot in the playoffs.
TV
Leinster v Leicester Tigers is live on RTÉ2 and RTÉ Player, with coverage getting under way at 7.35pm on Friday night. La Rochelle v Saracens
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