Fantasy playbook: NFL Week 6 score projections, over/unders and more

Welcome to the Week 6 Fantasy Football Playbook!

This will be your guide to the week's slate of NFL games, featuring score projections, over/unders, win probabilities and, of course, easily digestible fantasy advice for season-long and DFS leagues. This guide should help you with all sorts of decision-making, including sit/start decisions, last-minute waiver adds and lineup choices.

The advice is centered on 12-team PPR leagues with relatively standard scoring and lineup settings (1 QB, 2 RB, 3 WR, 1 Flex, 1 K, 1 D/ST), although I'll often mention «shallow» or «deep» leagues for some starters. The charts show all players who have been projected for at least 6.0 fantasy points this week, as well as all D/STs. «Matchup» is automatically determined using a proprietary metric that factors in raw and volume-adjusted fantasy points allowed to each position by the opposing defense this season.

(Editor's note: Projections and rankings will align almost perfectly, but sometimes when a projection is close, a player might be ranked slightly higher or lower because of other factors, including upside or risk. This column is subject to possible updates during the weekend, although at the very minimum, rankings will be updated on the site and projections will always be updated inside the game leading up to kickoff.)

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Lineup locks: Deebo Samuel

Marcus Mariota has a pair of top-10 fantasy outings this season (ninth both weeks), but he's not a streaming option against a 49ers defense allowing the fewest QB fantasy points and touchdowns (2) this season.

Jeff Wilson Jr. (16 carries and two targets on 35 snaps) ceded some backfield work to Tevin Coleman