Harry Kane was among five different scorers as Bayern Munich thumped Bochum 5-0 to move back to the top of the Bundesliga.
Michael Olise opened the scoring in the 16th minute before Jamal Musiala doubled the lead midway through the half.
Kane got in on the action just before the hour mark before Leroy Sane and Kingsley Coman completed the scoring for Bayern, who improved their goal difference advantage over RB Leipzig.
Union Berlin moved to fourth after being held to a 1-1 draw by Eintracht Frankfurt, who finished with 10 men.
Mario Gotze put the visitors in front after 14 minutes, but Benedict Hollerbach levelled in the 66th minute, with Eintracht's Arthur Theate collecting a second booking 10 minutes later.
Heidenheim and Hoffenheim played out a goalless draw in the evening fixture.
An own goal from Jose Maria Gimenez brought to an end Atletico Madrid's unbeaten start to the league season as they went down 1-0 to Real Betis.
Gimenez deflected Abde Ezzalzouli's cross into his own net just four minutes in, and Betis continued to push for a second, having a goal disallowed for offside, before Angel Correa twice hit a post for Diego Simeone's men late on.
Mauro Arambarri scored a last-minute penalty for Getafe to deny Valencia victory in a 1-1 draw. The visitors had gone in front through Enzo Barrenechea in the 36th minute.
Second-half goals from Diego Garcia, Darko Brasanac and Sergio Gonzalez gave Leganes a 3-0 win over Celta Vigo, while first-half goals from Lucas Torro and Ante Budimir gave Osasuna a 2-0 win at Real Sociedad.
Kenan Yildaz scored a late brace as Juventus recovered to snatch a point from a thrilling 4-4 draw at Inter Milan.
Piotr Zielinski scored two first-half penalties for Inter, opening the scoring and then
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