College football betting: How to bet Michigan-Oklahoma - ESPN

Michigan heads to Norman to face Oklahoma in Week 2 of the 2025 college football season. The Sooners have a quarterback with an elite arm, the Wolverines have retooled their offense, and both teams enter with plenty to prove after Week 1 matchups against softer competition.

If you're looking for value, there are edges to be found, but only if you know where to look.

All times Eastern. For latest lines, go to ESPN BET

No. 15 Michigan Wolverines at No. 18 Oklahoma Sooners
Saturday, 7:30 p.m., ABC

Line: Oklahoma -4.5, O/U 45.5
Money line: Michigan (+165), Oklahoma (-195)
Over/Under: 45.5 (O -105, U -115)

Based on both preseason expectations and Week 1 data, Michigan +4.5 deserves consideration. The Wolverines are built to challenge Oklahoma in ways Illinois State could not. Sooners quarterback John Mateer, the prized transfer from Washington State, brings explosiveness after accounting for 44 total touchdowns last season with the Cougars, but his mobility also helped hide protection concerns.

While he was sacked just once in Week 1, Oklahoma's offensive line graded poorly in run blocking, ranking 95th at PFF, and averaged only 3.2 yards per carry. Against a Michigan front that generated three sacks last week, staying ahead of schedule will be critical.

If the Sooners face too many third-and-longs, Mateer will be forced into high-risk throws against a defense that knows how to capitalize on mistakes. Michigan's secondary thrives on disruption, forcing three interceptions against New Mexico last week after ranking 24th nationally in passes defended in 2024.

The Wolverines' offense finally looks balanced with more big-play potential having Bryce Underwood at quarterback. The freshman went 21 of 31 for 251 yards (8.1 yards per