Bills TE Dalton Kincaid (knee) ruled out Sunday vs. the Chiefs - ESPN

ORCHARD PARK, N.Y. — The Buffalo Bills will be without another key member of the offense against the Kansas City Chiefs as tight end Dalton Kincaid on Friday was ruled out for Sunday's game.

Kincaid — who is dealing with a left knee injury sustained in the team's win last week vs. the Colts — joins rookie wide receiver Keon Coleman in not being available to play for the Bills in the key AFC matchup (4:25 p.m. EST, CBS).

This will be the second game Kincaid has missed in his career and the first this season. The second-year tight end leads the team in targets (59) and is second in receptions (34). He has caught two touchdown passes this season.

«I mean, certainly you have to kind of pivot a little bit in some areas,» McDermott said about Kincaid being out. "[Offensive coordinator Joe Brady] has done a great job with that and the staff as well, and it is just a lot of communication, a lot of, 'Hey, what are we good at? What's this player best at?' And just trying to, at the same time, make sure that we're aware of what the Chiefs plan to do."

Without Kincaid, tight end Dawson Knox is likely to have a bigger role. When Kincaid was out for all but two plays in the second half vs. Indianapolis as he tried to return, the Bills still ran some 12 personnel (one running back, two tight ends) on nine plays with backup tight end Quintin Morris also in line to play more on offense with this absence, but Kincaid's absence will likely bring more 11-personnel usage in addition to other changes.

Coleman being out for a second straight game will give more opportunities to other receivers, like Mack Hollins, who had four catches for 86 yards vs. the Colts, although there is a remaining question mark as wide receiver Amari Cooper (wrist)