2025 NFL Wild Card Odds: Lines, Spreads for all 6 Games

Things are literally about to get wild in the NFL.

The wild-card round will kick off this upcoming weekend, with six matchups ready to go. 

Let's check out the odds for those games at DraftKings Sportsbook as of Jan. 7, as well as what to know about each game. 

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No. 7 Chargers @ No. 2 Patriots

Spread: Patriots -3.5
Moneyline: Patriots -192, Chargers +160
O/U: 46.5

What to know: The Pats had a great season … against the worst competition in the league. In terms of strength of schedule, New England had the easiest road in the NFL. Of its 14 wins, two were against teams that made the postseason field. In terms of the Chargers, they handed the Broncos one of their three losses on the season, and they also earned an overtime win over the defending champion Eagles. 

No. 6 Bills @ No. 3 Jaguars

Spread: Bills -1.5
Moneyline: Bills -112, Jaguars -108
O/U: 52.5

What to know: The Bills spent a majority of the season as the Super Bowl favorites. They split the season series with the Pats, with each team winning on the others' home turf. Reigning MVP Josh Allen has guided Buffalo to the playoffs each of the past six years, where it has suffered one wild-card loss to Houston, two division losses to the Chiefs, one division loss to Cincinnati and two conference title game losses to Kansas City. Lucky for the Bills, neither Kansas City nor Cincy is in the playoffs this season. As for the Jags, they started the season 5-4 and never lost again, entering the postseason with an eight-game winning streak, including victories against the Chargers and at