2025 NFL Odds Week 3: Lines, Spreads for all 16 Games

NFL Week 3 kicks off Thursday night, as the Buffalo Bills host the Miami Dolphins.

Here are the lines for every Week 3 matchup at DraftKings Sportsbook as of Sept. 18.

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(All times ET)

2025 NFL Week 3 Odds

THURSDAY, SEPT. 18

DOLPHINS @ BILLS (8:15 p.m., Prime Video)

Point spread: Bills -12.5 (Bills favored to win by 12.5 points or more, otherwise Dolphins cover)
Moneyline: Bills -850 favorites to win; Dolphins +575 underdogs to win
Total Over/Under: 49.5 points scored by both teams combined

SUNDAY, SEPT. 21

PACKERS @ BROWNS (1:00 p.m., FOX)

Point spread: Packers -8.5 (Packers favored to win by 8.5 points or more, otherwise Browns cover)
Moneyline: Packers -485 favorites to win; Browns +370 underdogs to win
Total Over/Under: 41.5 points scored by both teams combined

COLTS @ TITANS (1:00 p.m., CBS)

Point spread: Colts -4.5 (Colts favored to win by 4.5 points or more, otherwise Titans cover)
Moneyline: Colts -198 favorites to win; Titans +164 underdogs to win 
Total Over/Under: 43.5 points scored by both teams combined

BENGALS @ VIKINGS (1:00 p.m., CBS)

Point spread: Vikings -3 (Vikings favored to win by 3 points or more, otherwise Bengals cover)
Moneyline: Vikings -170 favorites to win; Bengals +142 underdogs to win
Total Over/Under: 41.5 points scored by both teams combined

STEELERS @ PATRIOTS (1:00 p.m., CBS)

Point spread: Steelers -1.5 (Steelers favored to win by 1.5 points or more, otherwise Patriots cover)
Moneyline: Steelers -125 favorites to win; Patriots +105 underdogs to win
Total Over/Under: 44.5 points