2025 NFL Odds Week 1: Lines, Spreads for all 16 Games

Alas, preseason is over. No more dress rehearsals. The real deal is here.

It’s time to start betting on real games.

The defending Super Bowl champion Philadelphia Eagles kicked things off Thursday night with a 24-20 win over the rival Dallas Cowboys.

Friday brought the NFL’s second-ever regular-season game in South America, with the Los Angeles Chargers edging the Kansas City Chiefs 27-21 in São Paulo.

With a loaded Week 1 slate, let's check out the lines for each game at DraftKings Sportsbook as of Sept. 6. 

(All times ET)

2025 NFL Week 1 Odds

THURSDAY, SEPT. 4

COWBOYS @ EAGLES (8:20 p.m., NBC)

Philadelphia Eagles 24, Dallas Cowboys 20

FRIDAY, SEPT. 5

CHIEFS @ CHARGERS (8:15 p.m., YouTube)

Los Angeles Chargers 27, Kansas City Chiefs 21

SUNDAY, SEPT. 7

RAIDERS @ PATRIOTS (1 p.m., CBS)

Point spread: Patriots -2.5 (Patriots favored to win by 2.5 points or more, otherwise Raiders cover)
Moneyline: Patriots -148 favorites to win(bet $10 to win $16.76 total); Raiders +124 underdogs to win (bet $10 to win $22.40 total)
Total Over/Under: 44.5 points scored by both teams combined

STEELERS @ JETS (1 p.m., CBS)

Point spread: Steelers -3 (Steelers favored to win by 3 points or more, otherwise Jets cover)
Moneyline: Steelers -155 favorites to win(bet $10 to win $16.45 total); Jets +130 underdogs to win (bet $10 to win $23.00 total)
Total Over/Under: 37.5 points scored by both teams combined

DOLPHINS @ COLTS (1 p.m., CBS)

Point spread: Colts -1.5 (Colts favored to win by 1.5 points or more, otherwise Dolphins cover)
Moneyline: Colts -112 favorites to win(bet $10 to win $18.93 total); Dolphins -108 underdogs to win (bet $10 to win $19.26 total)
Total Over/Under: 47.5 points scored by both teams combined

CARDINALS @ SAINTS