The Baltimore Orioles cashed in three runs thanks to sloppy defence and poor pitching from the Toronto Blue Jays in the fourth inning to take the series opener 7-3 on Monday.
The victory was the ninth in 13 games for the Orioles (60-55), while the Blue Jays (61-53) continued to stumble with two wins in nine outings.
Toronto fell behind 3-0 but rallied for two runs in the third inning thanks to a two-run single from Lourdes Gurriel Jr. before 26,769 at Rogers Centre.
Mateo moved to second when Baltimore's Terrin Vavra walked and advanced to third after Kikuchi's throwing error on a pickoff attempt at second base.
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