Rampant Manchester United are eager to inflict more pain on Liverpool at Anfield as Arsenal aim to pull further clear of Manchester City in the Premier League title race this weekend.
The Gunners are hot favourites to see off Bournemouth at the Emirates, while City face a Newcastle side hoping to put the bitter disappointment of their League Cup final defeat behind them.
Tottenham must bounce back quickly from an FA Cup exit to maintain their advantage over Newcastle and Liverpool in the race for a top-four finish.
AFP Sport looks at some of the key talking points ahead of the weekend's action in the English top flight. United's revenge mission Liverpool won both Premier League fixtures against fierce rivals United last season by an aggregate score of 9-0.