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Ohio State Buckeyes at Penn State Nittany Lions betting, predictions, odds, picks, lines - ESPN

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Saturday brings us another huge matchup when the No. 3 Penn State Nittany Lions (7-0, 4-0 in conference) host the No. 4 Ohio State Buckeyes (6-1, 3-1) in a matchup of Big Ten powerhouses.

Ohio State (+425) is the second choice to win the national championship at ESPN BET, trailing only the Georgia Bulldogs (+360).

The Buckeyes are one spot ahead of Oregon (+475), despite losing to the No. 1 Ducks just two weeks ago. Penn State is 14-1 to win it all.

At -900 and -600, respectively, Ohio State and Penn State are heavy favorites to reach the 12-team College Football Playoff.

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