Cristiano Ronaldo has had to get used to life on the bench under Erik ten Hag but a first half injury to Anthony Martial gave the five-time Ballon d'Or winner the chance to reach another incredible goalscoring landmark.
United trailed after just five minutes at Goodison Park as Alex Iwobi curled into the top corner. But the Red Devils struck back quickly through Antony's third goal in as many Premier League games.
Ronaldo then latched onto Casemiro's pass to fire low past Jordan Pickford and move United up to fifth in the table. Earlier, Gianluca Scamacca's delightful chip helped West Ham strike back from a goal down to beat Fulham 3-1.
Fulham were without talisman Aleksandar Mitrovic through injury but went in front after just five minutes when Andreas Pereira smashed in from a narrow angle.