Will Colts keep up with 49ers? Play McCaffrey, Taylor in DFS? Betting advice for 'Monday Night Football' - ESPN

Week 17 wraps up with the San Francisco 49ers visiting the Indianapolis Colts on «Monday Night Football.»

San Francisco has clinched a playoff spot, meaning three teams from the ultra-competitive NFC West are in. The Colts desperately need a win to keep their playoff chances alive.

The 49ers are riding a four-game winning streak, while the Colts have lost their last four.

The 49ers are 5.5-point favorites Monday night.

Matt Bowen, Liz Loza and Pamela Maldonado offer their picks, prop bets, DFS plays and analysis to help you bet the game.

Note: Odds by DraftKings and subject to change.

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Total points UNDER 46.5 (-115)

Maldonado: This is volume without speed. Both offenses are fine taking what's there, running the ball and moving in chunks instead of going for home runs. That keeps the clock moving and limits total possessions. The 49ers can score, but they're more methodical, and the Colts want to grind with the run while still breaking in Philip Rivers. That combo usually turns into long drives, a few field goals and points coming slower.

Under

Under

Under

Brock Purdy OVER 246.5 passing yards (-112)

Bowen: 49ers coach Kyle Shanahan will have answers for the Colts' single-high and split-safety coverages, giving Purdy defined reads and vacated windows to deliver the ball. Plus, this Colts defense has allowed 252.6 passing yards per game over their last five. Bet the over.

Rivers over 17.5 completions (-124)

Loza: Rivers completed 18 of 27 passes last week after nearly five years of retirement against a fierce Seattle Seahawks defense that brings pressure at the fourth-highest rate. This go-around, he will have shaken off the rust, is playing at home and is battling a 49ers'