Which 10 Players Have The Best Odds to Win 2025 Offensive Player of the Year?

Last season, Saquon Barkley dazzled the NFL world in his debut season with the Eagles, helping Philadelphia win Super Bowl LIX and earning 2024 NFL Offensive Player of the Year honors along the way.

However, 2025 is a new year, and anything is possible. That said, who's the favorite to win 2025 OPOY?

Here are the 10 players with the best odds to do just that, according to DraftKings Sportsbook.

Christian McCaffrey only played in four games for the 49ers last season. (Photo by Cliff Welch/Icon Sportswire via Getty Images)

McCaffrey's 2024 campaign was a disaster, with the superstar running back playing just four games due to calf, Achilles and knee issues. At the same time, the two-time All-Pro is just one season removed from rushing for an NFL-high 1,459 yards and 14 touchdowns on 5.4 yards per carry, while tallying 67 receptions for 564 yards and seven touchdowns, all of which helped him become a finalist for the 2023 NFL MVP Award and win 2023 Offensive Player of the Year honors. The slippery back has electric speed, is elusive and also an essential element of San Francisco's passing game. A healthy McCaffrey has been arguably the best running back in the NFL in recent memory.

CeeDee Lamb is entering the first season of a four-year, $136 million contract with the Cowboys. (Photo by Sam Hodde/Getty Images)

Lamb continues to make No. 88 shine bright. A four-time Pro Bowler and 2023 All-Pro, Lamb has totaled 1,100-plus receiving yards in each of the past four seasons and 100-plus receptions in each of the past three. Last season, Lamb logged 101 receptions for 1,194 yards and six touchdowns in 15 games in a year that saw quarterback Dak Prescott miss nine games due to a hamstring injury. Lamb has led Dallas in receiving