Ultimate fantasy playbook 2022 - Week 1 score projections, over/unders and more

Welcome to the Week 1 Fantasy Football Playbook!

This will be your game-by-game guide to the week's slate of NFL games, featuring score projections, over/unders, win probabilities and, of course, easily digestible fantasy advice for both season-long and DFS leagues. This guide should help you with all sorts of decision-making, including sit/start decisions, last-minute waiver adds and lineup choices.

The advice is centered on 12-team PPR leagues with relatively standard scoring and lineup settings (1 QB, 2 RB, 3 WR, 1 Flex, 1 K, 1 D/ST), although I'll often mention «shallow» or «deep» leagues for borderline starters. The charts show all players who have been projected for at least 6.0 fantasy points this week, as well as all D/STs. «Matchup» is automatically determined using a proprietary metric that factors in both raw and volume-adjusted fantasy points allowed to each position by the opposing defense this season.

(Editor's note: Projections and rankings will align almost perfectly, but sometimes when a projection is close, a player might be ranked slightly higher or lower due to other factors, including upside or risk. This column is subject to possible updates during the weekend, although at the very minimum, rankings will be updated on the site and projections will always be updated inside the game leading up to kickoff. Also note that for Week 1, matchups are based on 2021 data and only included for reference.)

Lineup locks: Alvin Kamara, Kyle Pitts

Jameis Winston is a streaming option right out of the gate against an Atlanta defense that allowed the second-most QB fantasy points in 2021 and looks even shakier on paper entering 2022.

The Saints' elite run defense is back after allowing the fewest RB fantasy points