Texans star Joe Mixon's preseason in jeopardy due to latest injury setback

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Training camps opened across the NFL this week, and the Detroit Lions and Los Angeles Chargers will meet in Canton, Ohio, July 31 to officially kick off the preseason.

As the excitement for the 2025 season builds, at least one running back will likely spend the month of August watching from the sideline. 

Houston Texans star Joe Mixon's persistent ankle issue is expected to keep him from suiting up this preseason. 

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Houston Texans running back Joe Mixon rushes during the first quarter Oct. 31, 2024, in East Rutherford. (Imagn)

The two-time Pro Bowler will likely undergo further evaluation closer to the beginning of the regular season, according to ESPN. The Texans are scheduled to square off against the Los Angeles Rams Sept. 7 in Week 1.

The NFL Network was first to report Mixon's injury. 

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Mixon started training camp on the non-football injury list. The roster designation came after Mixon appeared to sustain an ankle injury earlier this offseason. He didn't take the field during minicamp.

Joe Mixon of the Houston Texans warms up before a game against the Baltimore Ravens at NRG Stadium Dec. 25, 2024, in Houston, Texas. (Alex Slitz/Getty Images)

This isn't the first time Mixon has battled ankle problems. He was sidelined for three games in 2024 after aggravating his ankle. Mixon also sat out two games in 2022 with a concussion. 

He dealt with a couple of apparent ankle sprains in 2021, although he still managed to appear in 16 games that season. A