Southampton vs Manchester United prediction and odds - bank on Reds to come away from St Mary's with three points

Check out our 21/10 Southampton vs Manchester United prediction below

What a difference even just one game of football can make. Rarely has the mood around a team taken such a marked shift in momentum as around United after Monday night's win over Liverpool.

Having stunk the place out in their opening two games, United didn't look capable of beating any side in the division but they now head to St Mary's as worthy odds-on pokes (31/40 with Betway) to back up Monday's success. Southampton are are 16/5 to follow up their 2-1 win at Leicester last weekend.

The club's ownership issues will always continue to rumble away in the background but on the pitch, there was so much for United fans to be positive about from the Liverpool game. Not least a defensive unit that inspires confidence. The partnership of Raphael Varane and Lisandro Martinez isn't flawless but the latter in particular already looks just the sort of warrior the fans will love.

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Harry Maguire is still likely to come in for games in which United are expected to dominate possession because he's the most progressive ball player United have in that position - for all that he's not particularly popular among all the fans.

It was a huge night for Marcus Rashford too - a player who was completely written off by huge sections of the fanbase. Rashford has looked utterly devoid of confidence for months now but he looked a revitalised performer on Monday. Not only did he show the sort of desire the fans have been craving - he topped running and sprinting stats on the night - but the confidence he will surely take from finishing that gilt-edged one-on-one with Alisson