Patrick Mahomes' five touchdowns baffles Cardinals as Chiefs collect statement Week 1 win

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Patrick Mahomes threw for 360 yards and five touchdowns, lifting the Kansas City Chiefs to an impressive 44-21 road win over the Arizona Cardinals on Sunday in the opener for both teams.

The game was never in doubt after the opening minutes, with Mahomes picking apart the Cardinals' defense with his usual array of good decisions and deft passing touch. The quarterback was playing his first NFL game against Kliff Kingsbury, who coached Mahomes in college at Texas Tech and now leads the Cardinals.

The student put on quite a show for his mentor: The 2018 MVP threw three touchdown passes on Kansas City's first three drives.

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Quarterback Patrick Mahomes #15 of the Kansas City Chiefs completes a pass during the third quarter of the game against the Arizona Cardinals at State Farm Stadium on September 11, 2022 in Glendale, Arizona. (Norm Hall/Getty Images)

Tight end Travis Kelce caught eight passes for 121 yards and a touchdown. It was his 30th career game with at least 100 yards receiving. Clyde Edwards-Helaire hauled in two touchdown passes.

Kansas City outgained Arizona 488 yards to 282. Mahomes completed 30 of 39 passes.

The onslaught started in a hurry.

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Kansas City jumped out to a 7-0 lead on the opening drive, capping an 11-play, 75-yard march with a 9-yard touchdown pass from Mahomes to Kelce. The Chiefs pushed ahead 14-0 later in the first on a nifty play from Mahomes, who threw an underhanded shovel pass to Edwards-Helaire for the 3-yard score.

The Chiefs led 23-7 by halftime after Harrison Butker, who missed part of the first half with a left ankle