NFL Week 6 predictions: Upsets, fantasy sleepers, stat lines - ESPN

Week 6 of the 2026 NFL season is underway after the Broncos beat the Seahawks in overtime Thursday night. But what will happen in the remaining 13 games? We have 15 predictions from our NFL experts.

First, betting analyst Pamela Maldonado picks three underdogs who could win outright. Then, analytics writer Seth Walder projects stat lines for three players. Fantasy football writer Eric Moody suggests three sleepers, and analyst Matt Bowen predicts three players who will find the end zone. Finally, analyst Ben Solak lays out three wild-card predictions.

Could the Texans pull off an upset in London? How many sacks will Chiefs defensive tackle Chris Jones have against the Chargers? Could Rams tight end Tyler Higbee be a sneaky play in fantasy? Will Falcons wide receiver Drake London find the end zone for the first time this season? And will Aaron Rodgers move up in the NFL record books against the Bucs? Let's make 15 big predictions for the Sunday and Monday action.

Jump to:
Upset picks | Projected stat lines
Fantasy sleepers, surprises
TD scorers | Other predictions

Dallas Cowboys +1.5 (+102 moneyline) at Green Bay Packers

The Packers have allowed the eighth-fewest passing yards per attempt this season, but this matchup presents a much tougher test than the backup quarterbacks they've faced in the past two weeks. The Cowboys convert nearly half their third downs and lead the league in the percentage of possessions producing points. Green Bay can hit big plays, but the Cowboys have enough on offense with Dak Prescott, CeeDee Lamb and George Pickens to answer.

New York Giants +1.5 (+108 moneyline) vs. New Orleans Saints

The Giants have a way to make this Sunday easier for quarterback Jameis Winston. They can run against a