NFL Week 5 picks, predictions, schedule, odds, fantasy tips - ESPN

Week 5 of the 2026 NFL season is here. Can the Raiders get back on track against the Patriots after losing their first game of the season? Will the undefeated Vikings keep rolling against the Saints? Who has the edge in Bears-Packers? How will Eagles-Jaguars play out in another edition of London football? And what can we expect from the 49ers' visit to Seattle?

We're here to get you ready for the action. First, our NFL Nation reporters take you inside the locker room with the best thing they heard this week, and ESPN Research provides a key stat to know. Then, analytics writer Seth Walder makes a bold prediction for each matchup, NFL analyst Ben Solak gives one reason to tune in to each game, fantasy analyst Eric Moody shares fantasy football intel, and betting analyst Pamela Maldonado hits betting insights for each contest. We also have Football Power Index (FPI) game projections, and Maldonado, Moody and Walder all give us final score picks for every game.

Let's get into the full Week 5 slate, which culminates with a «Monday Night Football» matchup between the Bills and Rams on ESPN. (Game times are Sunday unless otherwise noted, and all odds are via DraftKings.)

Jump to a matchup:
PHI-JAX | CHI-GB | LV-NE
MIN-NO | CIN-MIA | IND-PIT
HOU-TEN | NYG-WSH | CLE-NYJ
DEN-LAC | SF-SEA | DET-ARI
BAL-ATL |BUF-LAR

Thursday: TB-DAL
Bye: KC, CAR

9:30 a.m. ET | NFL Network | JAX -7.5 (41.5 O/U)

What we're hearing on the Eagles: Philadelphia entered the week with significant offensive problems. The Eagles have gone three-and-out on a league-high 15 possessions and rank 25th in points per game (18.8), 29th in total yards per game (269.8) and are tied for fourth in most sacks allowed (12). Things went from bad to worse with right