Men's March Madness 2025 - betting odds, lines, totals - ESPN

The 2025 men's NCAA tournament began with 68 teams looking to raise a banner and write their name into college basketball history. The Auburn Tigers, the overall No. 1 seed in the South, are looking to avenge their SEC tournament loss and claim the title as the best team in the country.

The SEC made a big statement in sending 14 teams to the Big Dance but faces stark competition from a formidable Houston team and the return of a healthy Cooper Flagg to the Duke Blue Devils.

Here are the lines, spreads and totals from each of the second-round matchups.

Odds are accurate as of publication time. All times Eastern. For the latest odds, go to ESPN BET.

(12) McNeese Cowboys
(4) Purdue Boilermakers -6.5
Men's Basketball Championship — Midwest Region 12:10 p.m. Amica Mutual Pavilion, Providence, RI

McNeese: 27-6, 19-1 in Southland play
Purdue: 22-11, 13-7 in Big Ten play

Odds by ESPN BET Moneyline: Purdue (-270), McNeese (+220) Total: 142.5

BPI Projection: Purdue by 7.6, straight up: 77%

(10) Arkansas Razorbacks
(2) St. John's Red Storm -7.5
Men's Basketball Championship — West Region 2:40 p.m. Amica Mutual Pavilion, Providence, RI

Arkansas: 20-13, 8-10 in SEC play
St. John's: 30-4, 18-2 in Big East play

Odds by ESPN BET Moneyline: St. John's (-340), Arkansas (+270) Total: 144.5

BPI Projection: St. John's by 5.6, straight up: 71.1%

(5) Michigan Wolverines
(4) Texas A&M Aggies -2.5
Men's Basketball Championship — South Region 5:15 p.m. Ball Arena, Denver, CO

Michigan: 24-9, 14-6 in Big Ten play
Texas A&M: 22-10, 11-7 in SEC play

Odds by ESPN BET Moneyline: Texas A&M (-155), Michigan (+135) Total: 140.5

BPI Projection: Texas A&M by 2, straight up: 57.9%

(11) Drake Bulldogs
(3) Texas Tech Red Raiders -6.5
Men's Basketball Championship —