Jimmy Garoppolo, Jeff Wilson guide 49ers to big win vs Panthers

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Jimmy Garoppolo threw for 253 yards and two touchdowns, Emmanuel Moseley returned an interception 41 yards for a score and the San Francisco 49ers beat the Carolina Panthers 37-15 on Sunday for their first road victory of the season.

Jeff Wilson ran for 120 yards and a touchdown and Tevin Coleman scored twice for the 49ers (3-2) after being elevated to the active roster this week.

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San Francisco 49ers running back Tevin Coleman, right, celebrates after scoring with wide receiver Deebo Samuel during the first half an NFL football game against the Carolina Panthers on Sunday, Oct. 9, 2022, in Charlotte, N.C.  (AP Photo/Rusty Jones)

Christian McCaffrey had 104 yards from scrimmage and a touchdown for the Panthers, who fell to 1-4 on the season and 11-27 under embattled coach Matt Rhule.

San Francisco’s defense came in having allowed an NFL-best 37 points through four games, and has now held all five opponents to fewer than 20.

The 49ers flustered Baker Mayfield all day despite losing top pass rusher Nick Bosa to a groin injury. Mayfield finished 20 of 36 passes for 215 yards and has as many interceptions (four) as touchdown passes since his arrival in Carolina.

Tevin Coleman, who had four touchdowns for the 49ers in a 51-13 win over Carolina in 2019, was a big factor early. He scored on a 9-yard screen play before outjumping a Carolina defender to haul in 30-yard reception, leading to a Robbie Gould's 49-yard field goal.

Carolina Panthers running back Christian McCaffrey is tackled by the San Francisco 49ers during the first half an NFL football game on Sunday, Oct. 9, 2022, in Charlotte,