Derrick Henry leads Titans to win over Colts with season-high rushing total

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Derrick Henry rushed for a season-high 114 yards and one touchdown and Tennessee's defense held up late Sunday to preserve the Titans' 24-17 victory.

Tennessee (2-2) has won a franchise-record four straight in the series and improved to 11-2 against AFC South opponents since 2020.

Indy (1-2-1) has one win in its past six games and blew late three scoring chances that could have cut the deficit to less than seven.

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Tennessee Titans running back Derrick Henry leaps past Indianapolis Colts safety Rodney Thomas II for a touchdown in the first half of an NFL football game in Indianapolis, Fla., Sunday, Oct. 2, 2022. (AP Photo/AJ Mast)

The Titans followed a familiar script by leaning heavily on the two-time NFL rushing champ early and held on despite scoring no second-half points for the second consecutive week.

Henry broke a bone in his right foot during last season's trip to Indy and hadn't looked like himself in the first three games.

But on Sunday, his bruising style was back with a bang. Against the league's No. 3 run defense, Henry topped the 100-yard mark for the fifth time in six games against Indy and he only needed one half to do it as the Titans took a commanding 24-3 lead.

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Tennessee Titans quarterback Ryan Tannehill scramble away from Indianapolis Colts defensive end Tyquan Lewis in the first half of an NFL football game in Indianapolis, Fla., Sunday, Oct. 2, 2022.  (AP Photo/Darron Cummings)

Tennessee converted Matt Ryan's fumble on Indy's opening drive into a 7-yard TD pass from Ryan Tannehill to Robert