Defending champion Nadal hobbles out of Australian Open with injury
Nadal's elimination shakes up the men's draw and puts a twist in the Grand Slam titles race, with nine-times champion Novak Djokovic able to draw level with the Spaniard's 22 major championships should he take a 10th crown at Melbourne Park.
Nadal appeared to suffer a strain in his left hip area while running for a backhand deep in the second set at Rod Laver Arena and after receiving attention from a trainer he took an off-court medical time-out when trailing 6-4 5-3.
He returned grim faced to play out the match but his movement was clearly affected, particularly on his backhand side, paving the way for McDonald to end the Spaniard's bid for a third title at Melbourne Park.
Before the injury McDonald had played superbly to take the first set, going toe-to-toe with the 36-year-old Spaniard and winning most of the ferocious baseline exchanges.
Mission accomplished for @mackiemacster