Cristiano Ronaldo and Nemanja Matic to start - Manchester United predicted line up vs Atletico Madrid

Manchester United have the opportunity to progress to the quarter-finals of the Champions League this week.

United take on Atletico Madrid in the Round of 16 second leg in the Champions League after drawing 1-1 with Diego Simeone's side in the reverse fixture. Anthony Elanga scored from the substitute bench to salvage a draw for United in that match.

United were humiliated in the Manchester derby but responded with a 3-2 win over Tottenham on Saturday evening. Cristiano Ronaldo's hat-trick sealed the three points and he'll be hoping to get on the scoresheet again versus his favourite opponent on Tuesday night, as Ronald has scored 25 goals in 36 appearances throughout his career against Atletico.

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David de Gea is a former Atletico player and he looked fazed by the occasion at the Wanda Metropolitano Stadium. Regardless, he'll obviously start in between the sticks here. Dean Henderson will consider his options away from United this summer.

Diogo Dalot returned to United's starting line up against Tottenham at the weekend, however, while Dalot cleared the ball off the line to prevent a Spurs goal, he didn't have the strongest of games, so Aaron Wan-Bissaka might start instead.

Raphael Varane and Harry Maguire will start in the centre of defence but Ralf Rangnick has a decision to make at left-back.

Shaw tested positive for Covid-19 and was unavailable for the Tottenham match. Alex Telles started instead, but Shaw has returned to training and Rangnick might prefer to restore the England international to the starting XI for this important match.

Nemanja Matic made a significant impact on the game's momentum in the first