Cormac Izuchukwu and Gus McCarthy will make their Ireland debuts against Fiji on Saturday.
The 24-year-old Ulster back row and 21-year-old Leinster hooker are among seven changes to the starting XV that beat Argentina last weekend.
Jamie Osborne, Bundee Aki, Sam Prendergast, Jacob Stockdale and Craig Casey also come into the side for the Aviva Stadium clash (3.10pm), Ireland third game of the Autumn Nations Series.
After his impressive cameo off the bench last week, Osborne is named at full-back for his first start in green at Aviva Stadium, joining Mack Hansen and Stockdale in the Ireland back three.
Robbie Henshaw starts at outside centre and is joined in the midfield by Aki, while Prendergast is set for his first Test start in a half-back pairing with Casey.
In the pack, Andrew Porter and Finlay Bealham are either side of uncapped hooker McCarthy (below), who was initially named in the Autumn Nations Series squad as a training panellist.
Joe McCarthy continues in the second row and is joined by Tadhg Beirne, who moves forward from the back row, allowing Izuchukwu to come in for his debut at 6 having been a member of the summer tour squad to South Africa and the recent Emerging Ireland tour.
The 24-year-old has plenty of experience alongside him in the Ireland back row as Josh van der Flier is named at openside and captain Caelan Doris at number 8 to complete the starting XV.
On the bench, Rónan Kelleher, Tom O'Toole, Thomas Clarkson, Iain Henderson and Cian Prendergast provide the forward options for Farrell, while Conor Murray, Ciaran Frawley and Stuart McCloskey are the backline replacements.
Speaking ahead of Saturday’s game, Andy Farrell said: "There were signs of improvement last weekend and this week has been about
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