Colorado safety Shilo Sanders not expected to play against Caleb Williams, No. 8 USC: report

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The Colorado Buffaloes are facing their first test of adversity on Saturday as No. 8 USC rolls into Boulder. 

The Buffaloes are coming off a massive defeat against Oregon, looking thoroughly outclassed in Deion Sanders’ Pac-12 debut. The Ducks took a 35-0 lead into halftime and defeated Colorado 42-6. 

Colorado Buffaloes head coach Deion Sanders before the runout to take on the Oregon Ducks at Autzen Stadium September 23, 2023.  (Andy Cross/MediaNews Group/The Denver Post via Getty Images)

One of college football’s top offensives now comes to town, and Colorado is expected to be without one of its best defensive players. 

DEION SANDERS' SON HOSPITALIZED FOR 'PEEING BLOOD' AFTER COLORADO'S BRUTAL LOSS TO OREGON

Safety Shilo Sanders is doubtful and is not expected to play against USC, according to ESPN. 

Sanders, the son of Deion Sanders, did not practice this week after suffering a kidney injury that had him urinating blood. 

"I made a tackle and landed on my kidney, or something broke. So, I gotta go to the ER and get checked," Shilo Sanders said via the YouTube outlet Well Off Media. 

"Coach Prime" provided an update on his son’s condition on Tuesday, saying the hope was that he would be available for Colorado’s Week 5 matchup.

Colorado Buffaloes safety Shilo Sanders (21) on the sidelines late in the game against the Oregon Ducks in the quarter at Autzen Stadium September 23, 2023. The Buffs lost 42-6.  (Andy Cross/MediaNews Group/The Denver Post via Getty Images)

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"He's doing better," Coach Sanders said. "We went to the hospital right after we landed. He's doing much better.