Colorado-Oregon betting odds, tips, picks for Week 4 - ESPN

In Week 4 of the 2023 college football season, all eyes will be on Deion Sanders and No. 19 Colorado as they head to Autzen Stadium in Eugene, Oregon, to face Dan Lanning and No. 10 Oregon. The past three games have each proved to be a solid test for a Colorado team that went 1-11 last season and now stands just one game away from surpassing its preseason projected win total of 3.5 games. The game will also feature two high-powered offenses led by star quarterbacks Shedeur Sanders and Bo Nix. Each team will look to make its case for Pac-12 supremacy in what will be their final year in the conference.

From a betting perspective, this game offers an intriguing angle. The Buffs enter Saturday afternoon as 21-point underdogs with the total set at 70.5 points. The last time Colorado was a three-touchdown underdog, in Week 1 against TCU, they ended up winning outright and ranked in the AP Top 25 the following week. Will Coach Prime's magic continue in the Pac-12 opener? How should you approach betting on this game, and how does it affect the futures market for the Heisman Trophy?

Jorge Sedano, Matt Miller, Dalen Cuff and Kevin Haswell are here to break it all down and give their best advice heading into Saturday.

All odds are courtesy of Caesars Sportsbook

Matt Miller: If this game were in Boulder, I'd feel differently, but at Autzen Stadium with the students rocking the place for an early game will be electric — and that's something Colorado hasn't faced on the road yet (sorry, TCU). However, 21 points is a lot, and we have seen a ton of poise from the Buffs early this year. I'm taking the over, but Colorado to cover the spread (+21).

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Dalen Cuff: I think the magic