Cilic stuns Medvedev at French Open to set up clash with Rublev in quarter-finals

It took until the fourth round, but now it's the high-seeded men who are exiting the French Open.

No. 2 Daniil Medvedev bowed out with a 6-2, 6-3, 6-2 loss to No. 20 Marin Cilic in a matchup between two past U.S. Open champions at Court Philippe Chatrier on Monday night.

Medvedev joins No. 4 Stefanos Tsitsipas, last year's runner-up, on the way out of the bracket.

While only three of the top 10 women's seeds got to the round of 32 at this year's French Open, all of the top 12 men did. And all of the top eight men were in the fourth round.

WATCH l Medvedev falls in straight sets to Cilic:

Medvedev is the reigning U.S. Open champion but had been 0-4 at Roland Garros until getting to the quarter-finals a year ago. This time, the Russian won every set he played until running into Crotia's Cilic, the 2014 U.S. Open champion, who is now into his third quarter-final in 16 appearances in Paris.

Cilic's next opponent is seventh-seeded Andrey Rublev of Russia. They will play each other on Wednesday with a semifinal spot at stake.

Danish teenager Holger Rune has eliminated 2021 French Open runner-up Tsitsipas to reach his first major quarter-final in his Roland Garros debut.

Tsitsipas was the first member of the top eight seeds to leave the men's bracket.

Rune never had won a Grand Slam match until last week, going 0-2 in previous appearances at the sport's top four events.

WATCH | Rune roars back to take 4th and final set:

But the hard-hitting 19-year-old now joins sixth-seeded Carlos Alcaraz to make this the first Slam tournament with two teenagers in the men's quarter-finals since Hendrik Dreekmann and Andrei Medvedev at the 1994 French Open.

Rune had a bit of trouble closing things out against Tsitsipas after going up 5-2 in