Ciarán Frawley will start his third game in a row at out-half for Leinster, who make seven changes to the side that beat Munster for their BKT URC clash with Connacht on Saturday (7.35pm).
There are two uncapped players in the matchday 23, while Rabah Slimani is set to make his first start since joining from Clermont Auvergne over the summer after making two appearances off the bench so far this season.
It's a new-look front row with Slimani joined by Jack Boyle and academy hooker Gus McCarthy, while James Ryan captains the side from the second row where he is once again partnered by RG Snyman.
Max Deegan is in line to make his fourth appearance of the season, with Will Connors and James Culhane completing a changed back row.
Academy winger Andrew Osborne is the only change to the backline from Saturday's win, with his brother Jamie continuing his run of starting every game so far this season as he is named in the centre alongside Garry Ringrose.
Liam Turner retains his place on the other wing, with Hugo Keenan once more selected at full-back.
Jamison Gibson-Park is once again given the nod at scrum-half alongside Frawley.
Academy duo Hugh Cooney and Stephen Smyth are in line to make their debuts if they are introduced to the action.
Fintan Gunne rounds out a total of five academy players in the matchday squad as he hopes to make his third appearance of the season.
Andrew Porter provides some experience among the replacements while Thomas Clarkson will hope to continue his involvement in every game so far this season.
Brian Deeny and Scott Penny complete the forward reinforcements, while Ross Byrne is in line for his fifth appearance of the campaign.
Meanwhile, Connacht will be without Mack Hansen (above) with the Ireland
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