Christian McCaffrey's offensive explosion, 49ers' defense help stymie Falcons in win

Nick Wright breaks down the San Francisco 49ers’ injury concerns following Week 1. With Brock Purdy uncertain for Week 2 against the New Orleans Saints and George Kittle expected to miss a few weeks, Nick explains why these injuries could put San ...

Christian McCaffrey and the San Francisco 49ers’ defense had a night.

The star running back had 201 yards from scrimmage and two touchdowns as San Francisco topped the Atlanta Falcons, 20-10, on Sunday night.

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San Francisco 49ers running back Christian McCaffrey (23) celebrates his touchdown against the Atlanta Falcons in the first half of an NFL football game, Sunday, Oct. 19, 2025, in Santa Clara, California. (AP Photo/Godofredo A. Vásquez)

McCaffrey ran for 129 yards and scored two touchdowns on the ground. He also had seven catches for 72 yards. He got the scoring started in the second quarter when he helped put San Francisco on top 7-3. He then put the dagger into the hearts of Falcons fans when he was pulled and pushed into the end zone with 2:26 left in the game.

It was that kind of frustrating night for the Falcons.

Michael Penix Jr. was 21-of-38 for 241 yards and a touchdown. He was sacked twice and lost a fumble. But after two big wins against the Washington Commanders and Buffalo Bills, the Falcons’ offense was expected to have a little more firepower than what they showed against a depleted 49ers defense.

San Francisco 49ers defensive end Mykel Williams (98) celebrates in the first half of an NFL football game against the Atlanta Falcons, Sunday, Oct. 19, 2025, in Santa Clara, California. (AP Photo/Kelley L Cox)

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