Betting 49ers-Rams: Siding with the Rams and the under, plus props to consider - ESPN

Week 5 of the NFL season gets underway with a matchup of NFC West rivals when the San Francisco 49ers visit the Los Angeles Rams on «Thursday Night Football.»

Both teams are 3-1, with the Rams' lone loss coming in Week 3 against the Philadelphia Eagles thanks to a blocked field goal. The 49ers' defeat occurred Sunday to the Jacksonville Jaguars.

Los Angeles won both matchups last season on its way to the division title. Plagued by injuries, San Francisco finished last. For the NFC West crown this season, the Rams (+125) are a slight favorite over the 49ers (+175), who again have been hit by injuries, as Brock Purdy, Jauan Jennings and Ricky Pearsall are all out.

The Rams enter as 8.5-point favorites for Thursday's game, with the spread moving all the way from LA -3.5 due to the 49ers' injuries. The teams meet again in Week 10 in San Francisco.

Here are the odds and trends, plus picks, props and analysis from our experts to help you bet Thursday night's game.

Note: Odds at time of publication. For the latest updates, visit ESPN BET.

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San Francisco 49ers at Los Angeles Rams

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Christian McCaffrey to go OVER 57.5 rushing yards (-115)

Bowen: McCaffrey hasn't been efficient on the ground through the first four weeks, averaging only 3.3 yards per carry. However, he is seeing steady volume (17.3 carries per game), and Kyle Shanahan will continue to feature the run game — especially with San Francisco's wide receiver injuries. Take CMC to hit the over.

Blake Corum to go OVER 29.5 rushing yards (-125)

Moody: Corum has cleared this line in two of the past three games and has had at least eight rushing attempts in each of the past two. His usage is