Alabama at Missouri betting, predictions, odds, picks, lines - ESPN

The Alabama Crimson Tide are in unfamiliar territory. Following last week's loss to the Tennessee Volunteers in Knoxville, the Tide dropped eight spots in the AP rankings to No. 15 and currently would likely be on the outside looking in at the expanded College Football Playoff. Jalen Milroe's Heisman hopes also took a hit, as he fell from 12-1 to 40-1 to take the award.

However, Alabama is -115 to eventually make the playoff field and is among the top nine in terms of odds to win the national championship (20-1).

Meanwhile, the Missouri Tigers were able to slip past Auburn last weekend to improve to 6-1 on the season, but they still dropped two spots in the rankings to fall just outside the top 20. They are +380 underdogs to reach the CFP.

No. 15 Alabama heads into Saturday's matchup as a 16.5-point favorite over the No. 21 Tigers. Kickoff is at 3:30 p.m. ET on ABC/ESPN+.

Odds current as of publish time, courtesy of ESPN BET

Spread: Alabama -16.5
Moneyline: Alabama -800, Missouri +500
Over/under: 51.5 (Over -105/Under-115)

First-half spread: Alabama -9.5 (-115), Missouri +9.5 (-105)
First-half moneyline: Alabama -650, Missouri +400
First-half total points: 26.5 (Over -125/Under +102)

The line for the Alabama versus Missouri game has seen some movement, opening at Alabama -14 and pushing to -16.5 after Missouri quarterback Brady Cook's status moved from questionable to doubtful. This matchup is significantly impacted by injuries to key players, which could favor Alabama's chances of covering the spread as double-digit favorites.

Brady Cook has been a vital part of Missouri's offense, ranking sixth in the SEC in passing yards before his recent ankle injury against Auburn. Despite his injury, Cook led the comeback, showcasing