49ers to face Rams without quarterback Brock Purdy, key receivers in NFC West showdown

49ers' quarterback Mac Jones spoke about the San Francisco 49ers' 16-15 win against the Arizona Cardinals.

A short week was not kind to the San Francisco 49ers, and the team will be without key offensive pieces, including quarterback Brock Purdy, against the Los Angeles Rams on "Thursday Night Football."

Wide receivers Ricky Pearsall and Jauan Jennings will also be unavailable for the 49ers Thursday night.

Purdy missed Weeks 2 and 3 after suffering a toe injury in the season opener but returned in Week 4 against the Jacksonville Jaguars. During the 26-21 loss, Purdy’s toe injury flared up again.

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San Francisco 49ers quarterback Brock Purdy rolls out to pass against the Chicago Bears during the first half in Santa Clara, Calif., Dec. 8, 2024.  (Eakin Howard/AP Photo)

Mac Jones will make his third start of the season.

He filled in for Purdy in the previous games, completing 66% of his passes for 563 yards with four touchdowns and one interception over that span. The 49ers won both of those games.

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Jones is also dealing with a knee injury, but the 49ers said he was a full practice participant on all three of their injury reports this week. He has no game status heading into Thursday night.

Jennings is battling ankle and rib injuries, while Pearsall has been limited by a knee issue. The 49ers will turn to receivers Kendrick Bourne and Demarcus Robinson, the latter of whom made his season debut last week after serving a suspension.

San Francisco will also be without receiver Jordan Watkins (calf) and defensive end Robert Beal (ankle), while defensive tackle CJ West (thumb) is questionable.

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