49ers' George Kittle expected to miss 3-5 weeks with hamstring injury, while Brock Purdy uncertain for Week 2

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The San Francisco 49ers kept Christian McCaffrey on the field in their 17-13 win over the Seattle Seahawks, but another star offensive weapon is expected to miss multiple weeks after leaving the game early.

Tight end George Kittle, who scored the team’s first touchdown of the year on Sunday in Seattle, left the NFC West bout with a hamstring injury. That injury is expected to keep him out three to five weeks, according to NFL Network.

Head coach Kyle Shanahan made the announcement on Monday after the win, saying that Kittle would miss a "few weeks." Shanahan added that no decision has been made about placing Kittle on injured reserve.

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George Kittle #85 of the San Francisco 49ers looks on during the second quarter against the Seattle Seahawks during the game at Lumen Field on Sept. 7, 2025 in Seattle, Washington. (Steph Chambers/Getty Images)

While Kittle isn’t going to be playing this upcoming week, there is a chance that starting quarterback Brock Purdy may not play, either.

Shanahan said that Purdy is dealing with left shoulder and toe injuries, and he wouldn’t guarantee his quarterback would be able to play against the New Orleans Saints. Shanahan also said the toe was the worse of the two ailments.

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"Not sure, has to see how it heals and how the week goes on it," Shanahan said of Purdy.

If Purdy isn’t available for the 49ers, his backup is veteran Mac Jones, the