2025 NFL Week 3 betting - Thursday Night Football: Bills-Dolphins odds, picks - ESPN

The struggling Miami Dolphins won't get much of a reprieve after their late loss to the New England Patriots on Sunday, as they now turn around and welcome the AFC favorite Buffalo Bills to town.

The Bills are 2-0 coming off wins over the Baltimore Ravens and New York Jets. The spread on this game opened at 11.5, but has settled in at 10.5 on Thursday. Bills QB Josh Allen is currently the +300 favorite to win MVP at ESPN BET and carries a 20-7 record in prime-time games.

We asked our expert panel of Matt Bowen, Pamela Maldonado, Eric Moody and Seth Walder for their best picks and props ahead of Thursday night's action.

Note: Odds at time of publication. For the latest updates, visit ESPN BET.

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Game picks | Prop bets

Buffalo Bills at Miami Dolphins

Pamela Maldonado: Buffalo is averaging 35.5 points through two games, second most in the league. The Bills' offense is a product of balance. Josh Allen is efficient and James Cook has been a reliable RB1, both of which are allowing the Bills to finish drives. They are 6-for-6 in the red zone so far.

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Miami's defense is a mess, ranking last in EPA. Opponents are scoring on 75% of their drives, converting more than half of their third downs, and have allowed two quarterbacks to finish top-three in weekly fantasy scoring. The Dolphins are not down on their luck, they just lack structure. The concern with laying a big number is always the back door, but with a team total, you only need Buffalo to keep doing what it has been doing so far: produce. I'm isolating the Bills' efficiency against Miami's collapse.

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Matt Bowen: Achane had 90